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Diagnosis of Endometrial Biopsies and Curettings by Michael Mazur, , available at Book Depository with free delivery. Diagnosis of Endometrial Biopsies and Curettings: A Practical Approach. Veli Marjoniemi. x. Veli Marjoniemi. Search for articles by this author. Department of. Generally, this should comprise a formal curetting rather than an outpatient biopsy. An external Diagnostic algorithm for examination of endometrial biopsies.

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An endometrioid carcinoma with a papillary growth pattern may be misdiagnosed as diqgnosis serous carcinoma and, conversely, serous carcinoma with a glandular growth pattern and little or no papillary formation may be mistaken for an endometrioid carcinoma. Briefly, five criteria must be fulfilled for a diagnosis of EIN:. The potential benign mimics of endometrial hyperplasia are listed in box 1.

Stromal and glandular mitoses are commonly found in a proliferative endometrium. It furthers the University’s objective of excellence in research, scholarship, and education by publishing worldwide. As the malignant stromal component in adenosarcoma is sometimes subtle and low grade, adenosarcoma may present as recurrent endometrial polyps, with the correct diagnosis being made only after examination of multiple biopsies.

Hum Pathol 34 — In a small percentage of cases without these features, there is vaginal recurrence after hysterectomy. Difficulty arises when an endometrium from a truly postmenopausal woman as stated previously, some women with postmenopausal bleeding are not truly postmenopausal, but rather are perimenopausal, with irregular cycles shows proliferative activity without features of biopies.

In most cases, this is curative, unless the sarcomatous component is high grade or there is sarcomatous overgrowth or myometrial infiltration. To purchase short term access, please sign in to your Oxford Academic account above. If you originally registered with a username please use that to sign in. Progestin treatment of atypical hyperplasia and well differentiated carcinoma of the endometrium in women under age This may be of value in diagnosing endometritis on small biopsy specimens in which the superficial endometrium is preferentially sampled.


Chapman and Hall, — Histopathology 45 — Journal List J Clin Pathol diagnosid.

These are benign proliferations, and in this situation the presence of architectural complexity does not signify a hyperplastic process. Before biopsy, many women with abnormal uterine bleeding are already taking exogenous hormones, especially progestogenic compounds, to control the bleeding, and this information is not always ebdometrial to the pathologist.

Assessing the glandular architecture and cytology may be difficult, as the squamous elements can be so extensive that the underlying glandular component is almost totally obliterated. Cancer 56 — The interpretation of the relevance of an unassessable specimen or scant specimen rests with the clinician.

Gynecol Oncol 61 — When an endometrial biopsy is carried out for abnormal uterine bleeding, the pathologist should always consider the possibility of a polyp.

Tamoxifen is widely used as adjuvant therapy in the management of breast cancer. Int J Gynecol Pathol 18 — Int J Gynecol Pathol 21 — Nuclear features in atypical curettinsg, which, as stated earlier, are often subtle, include nuclear stratification, loss of polarity, nuclear rounding and the presence of nucleoli.

Adv Anat Pathol 9 — The management of adenofibroma and adenosarcoma is identical, comprising hysterectomy.


Interpretation of endometrial biopsies and curettings. The immunohistochemical distribution of leucocyte subpopulations in human endometrium.

Diagnosis of Endometrial Biopsies and Curettings : A Practical Approach

Assessing the underlying glandular architecture is problematic. A major problem is the distinction between simple endometrial hyperplasia and disordered proliferative endometrium, a term widely used, although the histological features are not well characterised. Don’t already have an Oxford Academic account?

An immunohistochemical study of lymphoid tissue in human endometrium. It is useful to have diagnosiss checklist of benign lesions other than those listed earlier, including biospies, placental site nodules and the various forms of epithelial and stromal metaplasias. In my experience, various aspects related to endometrial hyperplasia commonly create problems for pathologists. Generally, this should comprise a formal curetting rather than an outpatient biopsy.

Obstet Gynecol 90 — Home Contact Us Help Free delivery worldwide.

Diagnosis of Endometrial Biopsies and Curettings : Michael Mazur :

The pathological diagnosis is generally straightforward if the gynaecologist is aware of the presence diagosis a polyp, has conveyed this information to the pathologist and has removed the polyp intact.

Effects of tamoxifen on the endometrium Tamoxifen is widely used as adjuvant therapy in the management of breast cancer.

Diagnosis of Endometrial Biopsies and Curettings: These should be identified, evaluated and mentioned in the pathology report.